REST Trial

The REST trial is a PoCoG-administered randomised trial of an intervention targeting self-efficacy to self-manage cancer-related fatigue in people with a primary brain tumour.

REST is being conducted by researchers at the University of Sydney to examine the efficacy of a novel online program in helping people with a primary brain tumour to better manage their fatigue.

We are seeking people who:

  • Are aged 18 years or older

  • Have been diagnosed with a malignant brain tumour in the past

  • Experience fatigue

  • Have or are willing to create an email account and have access to the internet

What participation involves:

  • A brief phone call to confirm the study is suitable for the participant

  • A short online survey asking for some information about the participant

  • Doing an online program with six sessions across 12 weeks

  • Completion of a brief online survey 3 times during the study

  • Participants may be asked to take part in an interview about their experiences of being in this study.

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Participants can complete the program on their own or with support from a family caregiver or another person. Their choice will be recorded when they begin the program. ‍


If you are a patient and would like to participate in this trial, please see the participant flyer here, and register your interest on the link provided.


If you are a clinician and ‍would like to refer patients to this trial, please download and share the participant flyer and link as needed.


Please contact the research team at pocog.brains@sydney.edu.au if there are any questions.

Ethics Approval

The ethical aspects of this study have been approved by the Human Research Ethics Committees (HREC) of The University of Sydney [ethics reference: 2025/HE000433] and the Sydney Local Health District (CRGH Zone) [ethics reference: 2025/ETH01130].